Welcome aboard; I recommend the 2X on a revolver, for these reasons: Leupold, more forgiving eye relief and hence better for someone starting out, plus the 2 power being easier to use out to your 100 yards max, IMO.
As for hunting loads, if you are not a handloader, go with the better factory premium choices in 240 grain and up.
I agree with Gregg. In my experience of using handgun scopes on handguns since 1978, none are more forgiving of eye position than the Leupold. I have 17 (both 2X and 4X)in service on various handguns at the moment. I have never broken one. I have had 2 Burris and 1 T/C scope fail during the last 30+ years. One Burris is back at their factory for the second time now.
Any manufacturer can produce something that fails. I have the utmost confidence in Leupold. Burris, not so much, but I don't want to start a @#$%^& ing contest here.
If you were hunting in the heavily wooded eastern U.S., there's no question I would recommend the 2X. It is almost certainly all the magnification you will need. It is also a bit lighter and more compact than the 4X Leupold and Burris. Your 8 3/8" S&W is already a bit bulky.
Since you are hunting Muleys in the West, the day may come when you are more comfortable with scopes and want a bit more magnification. That would be the day to move to the 4X in my opinion. In any event, the sensible maximum range for even a Master marksman with a .44 Mag is around 100 yards.
With regard to ammo, I use 23 gr. of 296, CCI 350's and 240 Sierra JHC's in my Smiths, to my complete satisfaction.