+1 Om what Whitworth said. as far as a custom grip. But I also want to add, That Jack Huntington does an excellent job with his grip modification. After having this treatment done on my Bisley grip, I want it from now on. NO more knuckle busting. And also All my pistols wear custom grips.
When you have a grip that fits your hand, it improves things dramatically. It is nice knowing when the hammer is dropped on a heavy load that your knuckle is NOT going to be smashed. Some of us need to be able to wear gloves when hunting and that is near impossible with some setups. So the grip mod again, shines in this respect.