My favorite loads consist of 55 grain Hornady PSPs with a modest charge of AA1680, I'm not exactly sure how much as I'm at work right now...if you're interested let me know...
This is a load designed for Field Pistol Silhouette. It's not going very fast with the 55 grain bullet, but is very accurate with the 1:10 twist. I've never actually shot silhouettes with it, but it's a great, low cost plinking/fun load.
I've also had good success shooting prairie dogs with factory Winchester HP's. (I didn't have time to work loads up before a trip to visit family in Wyoming...)