What caliber? I loaded some .45 Colt BP shotshells using cut down .444 Marlin cases. The way I did it was to cut the .444 brass down to the same length as the cylinder, primed with Win WLP primers, added I think it was 2 cc of APP FFg, folded a half square of one ply toilet paper in on top of the powder and tamped it in, topped it off with 7 1/2 shot, and glued a piece of lightweight card stock in on top with clear nail polish.
With the .444's cut the same length as the cylinder, you have to squeeze the case mouth down some before you load it. I used my .44 mag sizing die and pressed each case into the die roughly 1/4" or so which lets the new cases fit in the cylinders of my Uberti 75 Remingtons.
I did some patterning at various distances. At five feet, it looked like all the shot hit a piece of typing paper and it would probably work for snakes. At ten feet, there were obvious gaps in the pattern. At fifteen feet a large skunk could crawl through the pattern unscathed...