I used the old tried & true Keith slug (250 gr) with 22 grs of 2400 in my 10 1/2" SBH, I think the shot was about 80-85 yds, don't have my notes in front of me right now but thats pretty close. I was using iron sights at the time. The slug made a complete pass through & he did a spectacular back flip & started rolling down the hill towards me, not fast but at the time it seemed fast!
I've taken a lot of game with that bullet but mostly 21 grs of 2400.

Dick