If you were limited to one handgun (heaven forbid), but just for the threads sake, humor me, AND you didn't handload, therefore were limited to factory ammo, what would you choose? And why?
I would go with a 5 1/2 or 6 inch 45 Colt and shoot either a 325 grain LFN or 335 ELFN. The 45 Colt properly loaded and there or a few manufacturers of properly loaded 300+ grain bullets. Gives up very little to a 454 (if anything) in the game fields
The 45 Colt does all of this very effectively in the low 30 thousand PSI range, making it a pleasure to shoot. Plus the fact that 6 rounds in the cylinder is the rule, not the exception