Well, there's plenty of cowboy action level ammo out there for the .45 Colt, but there are good heavy .45 Colt loads available from a number of manufacturers. I understood that we should take commercial ammo availability into account. That said, I too would opt for my .45 Colt Bisley with a 5 1/2-inch barrel.
I find the idea of one gun to be a very sad concept.