I have taken several deer with the 45ACP round in a 10 inch Contender. I worked up loads in +P cases that I clearly marked with primer sealant so I wouldn't use them in any of my 1911s.

I used a 220 cast LBT WFN. All were pass through broadside shots at 30 to 70 yards, and none traveled more than 25 yards.

Where I live, it is illegal to use a semi-auto handgun to deer hunt.