Sixty yds. or so is my personal limit and that has to be off a good rest[4 5/8th .45 Blackhawk.]Last deer was at 62 yds. quartering slightly away 250 gr xtp 2400 powder ran 50yds. I carry a scoped gun for longer ranges. I shoot all my open sighted guns to 180 yds. on steel and rocks but not game.
I would rather let him walk than take a chance on wounding and not recovering him. It sears my soul to wound an animal and not recover it, so when I drop a hammer its as sure a thing as I can make it. JMHO