I don't recommend that you shoot game at 200 with a 44 but 100-125 is very possible if it's scoped. With open sights, depending on the light conditions and the amount of cover the animal is in, 50-75 is more realistic. Keep in mind that a game animal is mobile (not static like a target) and they frequently blend in fairly well with their background. The biggest problem in making the longer shots is getting a good sight picture on the animal so you hit where you want. Of course the individual shooter's eyesight plays a big role too. Some are fortunate enough to have very good eyesight. I'm not so lucky.