Festus, You have received a lot of great advice. While I haven't been hunting squirrels quite as long as 500WE, I have spent a ton of time hunting them since 1970. In a single-action, the FA is tops. However, the Mark III offers great value and makes for a dandy small game pistol. Currently I have a Mark III from Volquartsen Custom (Deluxe conversion) that shoots like a laser beam. With either an Ultradot HD Micro or scope, this is impressive squirrel medicine. Having said this, I also have a match chamber T/C barrel that will hold its own with anything. Several great choices at your disposal. Best of luck in your pursuit.