I am VERY cautious with the first few cleanings. Before even chambering a round I will clean a barrel until the patches are stark white. It's amazing how dirty some manufacturers will ship a gun. Then I'll do a regiment just to make sure the barrel is in decent condition and free of any defects. After that normal group shooting begins with cleanings in between to make sure each load has the same barrel condition to ride through.

This goes for about any bottleneck cartridge or straight wall big boomer (45-70 for example). Smaller straight wall stuff gets the initial inspection cleaning then just shot.