Shoulder blades X3. The shattered bones are projectiles of their own and do additional damage.
Jacketed: in .475L only the 275 gr. X works great on deer. It's really beyond great-4to6" internal damage, 3" exits. Horn. XTPs, Gold Dots are too hard to perform well on deer for immediate reaction. They'll die, but in a while. Nice thing about the X is that it won't break up on deer. Do a shoulder shot and you get all the extra help from the bones. Do a lung shot and the hydrostatic forces from that massive HP does extremely good.