I owned a 454 Casull in the form of a Ruger SRH. I sold it because it seemed to be in the realm of the 44 magnum, caliber wise. Also, the recoil seems to be a short impulse that at my age was getting painful.

I bought a Ruger SRH in 480 a while ago and it is much more manageable.

So my vote goes to the 480