I also have the 460 Encore barrel. Once I got accustomed to the recoil, it has become by far the best long range handgun that I have. To date I have not shot anything but targets at long range. I would be comfortable under the right conditions and with a solid rest to take a shot up to 200 yards at a game animal. I shoot targets out to 300 meters but by then the drop becomes a significant factor and would not risk taking a shot at an animal at that range.