dave,

Welcome to HHM. I have one of those Redhawks and have fired 45 Colt and 45 ACP through it. Like the versatility. I have developed loads for my Blackhawk 45 Colt/45 ACP cylinder that shoot to the same point of impact. Therefore, sight adjustment is not necessary when switching ammo. Haven't had a chance to do that for the new Redhawk.

Doc