The 44 magnum is easier for finding a accurate load. Also, good ammo for it is readily available commercially. The 45 Colt in a strong frame is pretty well an equal on just about any game animal up to the dangerous game level. I have shot both for over 40 yrs and I wouldn't hesitate to grab either of the two for the animals listed. I have shot Russian hogs up to 450 lbs with both and properly loaded have seen no difference. I shot a 500+ lb cow elk with the 44 mag SRH and 300 WFN cast and every bullet was a pass through. My opinions are based on my own experience in the field. Ease and convenience go to the 44 magnum. Good luck with whatever you choose.