I've taken 5 really heavy bodied WV bucks with my 6" Python from 60 to 90 yards with 158 gr. XTPs and Sierra JHCs. I'm sure 180s will work, but you'll get a little more shock damage from the 158s. These deer ran from 0 to 40 yards.
Redhawks are great. Love my 5 1/2" .44.