I'm a .357 Maggie man through and through so that is my preference but......My opinion is whatever gun/caliber combination is best for you. Meaning whatever you shoot the best and are most comfortable with.
My old S&W 65 is not only my carry gun but it has also take and has few critters (four legged kind) along the way.
It feel good in my hand. I know it inside and out and it will eat anything I feed it with almost all the bullets impacting to close the same point of aim. Weird revolver for sure...
Now that rank is over....Best of luck to you.

P.S. Anyone know how many cents I am up to. Should be 11 cents worth of B.S by now......