Vance, I've been fortunate to take a few bears with the 375 JDJ using 270 grain Hornady spire points at 2070 fps. However I managed to take a really big brown bear with the 375/06 JDJ with the same bullet at approximately 300 fps faster. This would be my choice for a huge brown bear. Of course you could never go wrong with the 375 JDJ. Good luck with whatever you decide. MH