I never used Nosler handgun bullets, but I've used a bunch of the others over the years.
The "softest" with best expansion have been Rem. 240 gr. HPs.
Sierra 240/180 gr. JHCs are tougher, penetrate more, and cause less damage than the Rems. (Not true for Sierra rifle bullets. They seem much softer than other brands).
Gold Dots are much harder than the ones mentioned. Very little expansion in deer and none in groundhogs.
XTPs are the hardest of all. I've recovered a lot from angled shots on deer that were minimally expanded with little damage in the bullet track. The only one that ever worked good for me was the 200 gr. XTP in .45 auto. It put deer down extremely well. I don't know why it was good and the others weren't. I don't use XTPs on game.
Good ol' Kieth 250 gr. .44s do a surprisingly good job on most animals with decent internal damage especially in larger animals.