I have shot deer with many calibers. The deer I have shot with my FA83 .454 were all one shot kills. One of the first loads I used was a 250 Horn XTP with 30 gr IMR4227 [chrono'd 1470 fps] and this was a bang flop combination,but later switched to a 350 WFN [Matts] with 26 gr IMR4227 [chrono'd 1330 fps] that is very accurate. The deer usually run to 30 yds tops. I actually like the cast load better and it can be used in just about any situation.