With a .476' diameter bullet, I'd go with penetration because your bullet is "expanded" prior to pulling the trigger. For the most part, I'd stick to 1,000 to 1,200 fps loads in the larger calibers as increasing the velocity over this gets you mostly just more recoil and noise. I do have a .38-44 load using the Lyman 358429 that is getting right at 1,400 fps and I haven't shot a deer big enough yet to hold that bullet.