I have to admit that a 10mm wouldn't be my first choice (not enough margin for error for some one as trigger happy as myself), but I set up a G40 for a good friend of mine with a vortex red dot and an aftermarket barrel (1" longer than factory) with compensator. From a truck hood with a bag under the front end I could easily group the Buffalo Barnes loads (155gn TAC-TX chronoed at 1500 fps from the gun) at <2" at 50 yards.
If you have a good shooting position (for me that means a rest), are shooting full power 10mm loads with quality bullets and restrict your self to good double lung shoots then it should work ok. You have to remember you are shooting something that specs out very close to a 357 mag on paper. There have been lots of discussions here about the suitability of a 357 and the number of deer lost using them.

My gripe about the pistol was the striker trigger. Difficult to shoot good freehand groups for me.