I shot this coyote with a 250 grain Nosler Partition while deer hunting.

The shot was straight on at 56 paces. The bullet entered and exited the base of the neck. Obviously, that was lethal, but the wound didn't exhibit much bullet expansion.

If I was targeting coyotes specifically, I would want more speed and more expansion. Some might be concerned with pelt damage, I'm not, I want violence and destruction.