What is the difference in foot power for calibers? What am I not understanding? IE, for an extreme difference, a 55 grain 22 bullet going 3200 fps has about 1100 pounds of energy at 100 yards vs. a 240 grain 44 bullet going about 1800 fps with 1100 pounds of energy at 100 yards. They are both ballisticly possible. Please also understand that I would also rather shoot the 44. What am I missing?

To take the bullet equation out of the way, lets just say that both of the projectiles are partition or Barnes Triple-Shock X-Bullets™ .

Duane