IMHO, the 120 grain Nosler ballistic tip is the perfect projectile for any 7mm handgun. I use it in my 7-30 Waters 'Tender and .284 Winchester XP-100. For bigger than deer sized game you may want to go with a 140 but I use bigger bores for those. I see no reason to go any smaller, except for vermin and then the Hornady V-Max would suffice.