Haven't used the 454 stuff but i have taken whitetails with both the (460) 275 xpb and the (44) 225 xpb. both worked great one shot kills out to about 100 yards with the 460 and a closer 40 yd shot with the 44. I have just reloaded the 460 round using the 200 gr. xpb and am headed to the range tomm weather permitting I've heard good things about the 200 accuracy wise.