I have a 15 inch 460 S&W barrel. Yes you can shoot 45s and 454s in it. The 45s will shoot faster in a shorter barrel. In my gun the 45s are like shooting 38s, the 454s are like 44s, and the 460s are definately two handers. I could go on and on about this gun.

With God all things are possible. Matt.19:26