You may find that your choice of bullets is dictated by the length of your chambers throat. I currently load the Sierra 130 grain SSP bullet, but when I try to seat the bullet just off the lands I find that the bullet is not seated deep enough in the case. The Nosler reloading manual notes that " A seating depth of one bullet diameter inside the case neck gives good alignment and neck tension for ignition". I have been following this rule, and can not complain about accuracy 1" at 100 yards. I expect to be working up some loads this week using the Nosler 140 grain balistic tip just to see if getting closer to the lands will improve the accuracy. Unfortunately I haven't taken any deer with a handgun, so I can't comment on bullet performance on an actual deer.