I spoke to the owner of Cast performance. It was his recommendation to use the 4227. He said it was much more stable when it came to temp extremes. And we do get extremes here in Eastern NC. 100+ in the summer and in the teens in the winter. I have used H110 and 296 considerably in my 44mag and 357 mag. So 4227 is new to me. Can't wait to ge the scope and gun together and load up some ammo as well. Picked up a decent pistol rest today so that my sight in time should ge better then it has in the past.