My pick would be easy and I don't think there would be too much of a compromise for what I do.

Ruger or Browning 22 target pistol (I just use a 22 too much not to list)
223 Rem or 22-250 Winchester on T/C Contender or Encore
6.5x30-30 or 260 Rem on T/C Contender or Encore
35x444 or 35x308 on T/C Contender or Encore
44 Mag Revolver, single or double action Ruger w/ 6" to 8" barrel