I use 4227, and 4756.

For my 454 the 4227 works very well, I get nice groups and good velocity. But when I loaded it into by 45colt the cases took a beating, they bulged out to the point where I had a hard time extracting them (Ruger Super Redhawk).

A 250xtp over 9.5grn of 4756 makes a nice load, might be a little slow for heavy game but I think it would work well on white tail.