In my experience and YMMV I have found that it makers not is a rifle is used or a handgun if I do not want them to run the only way to guarenty that they do not is to place the bullet in such a matter as to take out stuctural support bones or CNS hits. I shot a deer with my 30-06 and took out the heart and both lungs and he took off at the shot, no blood on the ground or anything else to indicate a hit. Whne I found they deer about 30 yards away in the woods he fell with one leg pointing 180 degrees away from the other 3. The exit and internal damage was massive to say the least. In no way was there a bullet failure, sometime they just do amazing things whgenthey should not