Whitworth with a nice deer, revolver and cast.

What you need to do is to make the boolit work at the velocity and caliber to impart maximum damage where it is needed for the animal you hunt. It is exactly the same as when you chose a bullet for the game hunted.
It is harder with cast because bullet makers have improved results over a wide spectrum. They have done a super job making a bullet work over a wide range.
It really takes your own experience and the study of every animal. Just because you kill one deer is just not enough.
I will never look down on a good jacketed bullet. But economy demands I find a cast that will work and they really do everything if you pay attention.