My experience is right in line with ToddXP and LCRogers. My reloads with H-322 using Hornady 50 gr. SX (Super Explosive) has killed hundreds of prairie dogs and dozens of marmots, plus a dozen or so coyotes, and badgers, and foxes... 'n lots of other varmints...

Old school powder and bullet but works as good as any of the new ones on vermin.