I would use the 300 at 1350 for my hunting duties.
No need to beat yourself up now. I'm not sure you can get there in a wheelgun anyway but even @ 1,200FPS the 300 will kill with authority.
Reloading is absolutely worth it, moreso than just monetary savings which will allow you to shoot more. You can tailor a load for your liking, recoil versus terminal balistics, etc.
Plus, it is quality time with yourself.
