Also, it is my understanding that firing with an open chamber in the cylinder can cause further damage. What's your opinion?
I think it's hogwash. Take an empty 44 mag, 480 Ruger, any case you like and squeeze the mouth between your fingers. I can crush it flat with little effort. So if an empty case lends no strenght to a chamber in the cylinder I can't see where a empty chamber can be effected from firing the gun. If that were the case you would have to fire one round, open the gun and replace the fired case with a loaded one for support.
I do think the 480 Ruger suffers from a similar problem. Ruger with the SRH was convinced that 6 chambers were posible up to 475 cal. The 44 and 454 can take the high pressures as ther is enough material between chambers. The 480 gets a little thin between chambers. If loaded reasonable the design works. I think the extraction problem some people are having is due to the fact that they are loading the 480 up to 475 Linebaugh performanc. I have over 1,000 round thru my 480 and have never had a problem, but then I keep the loads reasonable. When Linebaugh does a conversion on a Ruger he uses a 5 chamber cylinder.