Ok I'm getting ready to start loading some hot rounds and want to know what primers y'all are using. The boolit is a 315 LFN hardcast and I will be using W296 powder and shooting these out of my 5.5" Bisley.

I would use mag only on 296 or 110
To pick a brand CCI

Winchester Large Pistol (WLP) is all you need for standard or magnum.

x2

Its all about brisance, the shattering effect of an explosive. Winchester primers have a little bit higher brisance than other manufacturers primers, CCI is a little milder. I don't load for the .45LC, but in my .41 mag I see very little real world difference because I work up to a load and playing with powder volume and crimp will typically sort out your ignition speed issues. Your milage may vary in that larger case, but I certainly wouldn't stress about magnum vs standard primers, use what you you've got and take good notes.

WLP

X3

It even says "For standard or magnum pistol loads" on the box.

X4

Winchesters are my go-to primers.

X5

I have tried a bunch of different primers and the results weren't as spectacular as one would think. With 296/110 a lot of manuals will say use mag primers,but from my testing they are not needed. Use what you have and don't worry about it. I found some differences in es and velocity but accuracy didn't suffer whether mag primers or standard primers were used.