Hi Shooter,
Congrat's on the antelope. I'll be heading to Gillette in 3 weeks for the 20th Handgun Hunters International shoot there. I can get 5 tags. Last year my son and I took 10 antelope in 4 days.
Anyway back to your issue. I find a big difference when switching barrels and frames. I shoot IHMSA and I have three Contender frames. I always match the barrels to specific frames. If I move barrels randomly between frames I get a change of POI as much as 2" and pressure indicators like cratered primers in one barrel and frame, and not with that same barrel when hooked into another frame.
I think that when we are working at the top of the pressure limits for a particular caliber even little changes can cause problems. Thats why everyone always says to drop 10% when starting with new loads, bullets or in your case...frames and barrels.
Bill in OR