I've had a couple one was life threating the other more a nuisance. When I was glassing for mulies I shot a badger that I had been watching cross a field. When he was within about 40 yds he saw me and instead of running away he charged and I hit him with a 475 linebaugh right behind the head. While he couldn't have killed me he had thoughts of gnawing on my leg.
The second was a cougar that I had spotted in a farmers field. I could not get under 200yds from it and all I had was my iron sighted 475 so the farmer let me borrow a Remington 7600 30-06 with a 30 year old scope and green ammo, the magazine was so rusted I had to beat it into the gun. I took a shot from what I later ranged at 187yds and the cat ran. I couldn't tell if I had shot over or if the bullet had passed through but I saw dust kick up behind the cat. I returned the rifle and went looking for sign. I couldn't find any blood so I started walking parallel to a blackberry hedge bordering between the field and a river checking all the trails going in. As I passed one trail my sixth sense kicked in and as I turned the cat started to come out from where it had been hiding in the brush waiting to ambush me. I was able to get a shot off with the 475 as I spun but I shot wide as I was trying to shoot across my body and behind me. The cat was only 5 or 6 feet away when I shot and luckily it turned and ran. I never did find any sign other than carcasses that showed this cat had been around for a while. I later found from tracks in the area that it was a female with a cub. The cat hasn't been seen since although I did get a shot off at what was presumably it's cub a few months later but it was a running shot off hand with my short barreled 475 and I missed. The farmer to this day is extremely gratefull since besides raising hay he also raises goats which is what we figure brought the cat in to begin with.