Fan,
I've had great accuracy and velocities with essentially no leading using the Lee 400 CWFN ( Brinell hardness 19, water quenched wheel weights ); Lee Alox tumble lube; Horn brass; Accurate #9, 20.7 grains OR H110, 20.9 grains ( RCBS Little Dandy powder measure rotor #22 ); Winchester magnum large pistol primer. These are not max loads, but near the upper end. Work up with caution. I've fired these loads in 2 1/2" to 18" barrels with no problems, including my 12" Encore barrel. Hope this helps!
Doc