I think that playing with the fraction of an inch(in a revolver) would be meaningless for most handgun hunters as most will probably be shooting at 50 yards or less.In a single shot,putting the bullet closer to the rifling may give it better accuracy,at least thats what I've read and I do that with my 7mm T.C.U. but to be honest I've not really done any testing to determine if it makes any difference.