This question does have a logical answer. "Yes"

They both have their places. I'm a 45 Colt guy after Linebaugh's readings. In fact both he and his son are both building guns for me.

Nothing wrong with the 44. I think the 44 special is pretty awesome. 250 Keith at 1100 fps. 45 Colt using 320gr LFN at 1100 is also impressive.

In the wheel guns, I like 1100 ish FPS. Adjust bore size and weight to take on larger targets.