Vance,
I've had good luck with H4227 using 300-grain bullets in my 44's in the past. One of the best loads in my guns is 20.0 of H4227 and a 300-grain Speer Uni-Core seated to the rear cannuler. This is very accurate out of a 4" S&W and penetrates completely on everything I've shot with it. Also there is no hint of preasure problems. The bad part about this bullet is there is no expantion so you really want to hit bone. Winchester 296 is my other choice for some reason I've always seemed to have preasure problems using H110. H4227 is also cleaner burning that the other two powders you mentioned but you will get higher velocities with 296 or H110.