Last year I used a 475L in a super redhawk with a 412gr @1075fps, and my all time favorite caliber 45colt in two Ruger converted bisleys,one with a 4 5/8"bl and the other 7 1/2"bl, with a 255gr @1100fps.
This year my new 500JRH will get most of the work but the 45colts will see some action also.