my point has always been that it's load dependent. i have loads that i shoot that are wholly inapproprate for raking shots on elk out of my 454, same way i wouldn't use a hornady 325 on certain shots out of my 475, but there are loads that are appropriate in the .41 and there's 500 smith loads i wouldn't wanna use. once you get the 41 and above imho its 99% about the bullet but it's always 100% about accuracy and if someone shoots it better than a larger caliber, use the .41