The 378 GNR is a great caliber. I have more confidence in this round than any other. My gun shoots 225 gr. Hornady's, 260 gr. Nosler BT's and Accubonds, and 270 gr. Hornady's into 1.5" at 100 yards. The 260 grains travel at 2345 fps. and I can push the 225 grain bullets to almost 2500 fps. if I choose. It is overkill for many of the animals I have taken, but dead is dead.