Okie,
I think a lot might depend upon whether you handload, and/or these other barrels are either in 10mm or can get your ballistics closer to 10mm. While I do not use a 10mm, there are lots of folks who do and it absolutely has a place in hunting some large game. I think I would feel a little more "undergunned" being serious with either the 40 S&W or typical 40 ammo you might buy. I think most of that might tend to fall into the personal protection category and perhaps not have the choice of bullet or application you want.
Craig