Defensive pistol rounds are designed for defense against two legged varmints..and they are by virtue of their case capacity and bullet selection pretty limited. I would never attempt to hunt big game with even a 45 acp. 10mm is my bottom line cartridge and my only gun is a s&w 6 in. revolver. Still I think you can get better performance than that from huntig loads for 357 magnum..Revolvers have the advantage over autos they get those 180 grain plus bullets moving along 1100,1200,1300, 1400fps thats what I call a hunting load, not sub 1000 fps.